When taken with a high fat meal by 12 healthy male volunteers, there was a decrease in the rate of absorption of pilocarpine from pilocarpine hydrochloride tablets. In five healthy elderly female volunteers, the mean C max and AUC were approximately twice that of elderly males and young normal male volunteers. Pharmacokinetics in elderly male volunteers (N = 11) were comparable to those in younger men. The AUC trapezoidal values were 33 h(ng/mL) and 108 h(ng/mL), respectively, for the 5 and 10 mg doses following the last 6 hour dose. T max values were 1.25 hours and 0.85 hours. In a multiple-dose pharmacokinetic study in male volunteers following 2 days of 5 or 10 mg of oral pilocarpine hydrochloride tablets given at 8 a.m., noontime, and 6 p.m., the mean elimination half-life was 0.76 hours for the 5 mg dose and 1.35 hours for the 10 mg dose. This effect of pilocarpine on salivary flow was time-related with an onset at 20 minutes and a peak effect at 1 hour with a duration of 3 to 5 hours (See Pharmacokinetics section). In a study of 12 healthy male volunteers there was a dose-related increase in unstimulated salivary flow following single 5 and 10 mg oral doses of pilocarpine hydrochloride tablets. Bradycardia and tachycardia have both been reported with use of pilocarpine. The expected effect of a muscarinic agonist is vasodepression, but administration of pilocarpine may produce hypertension after a brief episode of hypotension. Pilocarpine may have paradoxical effects on the cardiovascular system. The tone and motility of urinary tract, gallbladder, and biliary duct smooth muscle may be enhanced. Bronchial smooth muscle tone may increase. Dose-related smooth muscle stimulation of the intestinal tract may cause increased tone, increased motility, spasm, and tenesmus. When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitory rise in intraocular pressure followed by a more persistent fall. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. Para ver la lista en espanol, presione aqui.Pilocarpine is a cholinergic parasympathomimetic agent exerting a broad spectrum of pharmacologic effects with predominant muscarinic action. This list is available for download. (English) ![]() If you use sharps, learn how to dispose of them safely.Īlso, please keep in mind that the drop boxes are designed for collection of prescription medications only. Please note: None of the locations listed accept sharps (needles), thermometers, bloody or infectious wastes, or wastes from medical businesses. We recommend that you call locations in advance to make sure the hours are current and the drop box is not currently full. The sites listed below accept prescription medications, including controlled substances*, prescription samples, pet medications, medicated ointments or lotions, inhalers, and liquid medications in leak proof containers. Remove unwanted and expired medications from your home to reduce risks of accidental poisonings and prescription drug misuse. ![]() It also helps keep medications out of our drinking water, lakes, rivers, streams, and Puget Sound. Safe disposal reduces risks of accidental poisonings or intentional misuse. Safe and free disposal of unwanted and unused prescription medications is available.
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